Improving health and reducing inequities worldwide



E2Pi’s two major focus areas to date in its policy work on malaria have been:

  • Maintaining the gains of malaria control in countries that have reduced the malaria burden
  • The Affordable Medicines Facility - malaria (AMFm).

Maintaining the Gains

Thanks to aggressive campaigns to scale up control tools, many malaria-endemic countries have seen dramatic falls in malaria cases and deaths. Other countries are still in the scale-up stage, needing increased investment and commitment to reduce the high malaria burden. The gains that have been made so far are impressive, but they are fragile. If the successful countries were to reduce their malaria control activities while the potential for malaria transmission remains, all of the gains will be lost because malaria will rapidly resurge. Innovative approaches are needed to secure sustainable, long-term malaria financing and improve access to interventions for effective prevention, diagnosis, and treatment. E2Pi, working in close partnership with the African Leaders Malaria Alliance (ALMA) and the Clinton Health Access Initiative (CHAI), has conducted evidence synthesis and policy analysis on the health and economic benefits of sustained malaria control in these successful countries.


Launched in April 2009, the AMFm is an innovative financing mechanism designed to make artemisinin-based combination therapies (ACTs) more accessible in places where malaria is endemic and there are high levels of resistance to older anti-malarial drugs. The mechanism, which involves a donor-funded ACT price subsidy, is being piloted in eight countries. E2Pi was commissioned by the Global Fund to estimate “benchmarks” of success in the pilot phase. We are also collaborating with the Kenya Medical Research Institute and the Liverpool School of Tropical Medicine to conduct a systematic review of the impact of ACT price subsidies.

Examples of E2Pi’s Work on Malaria Include:

Maintaining the Gains: Country Briefs
On September 19, 2011, President Jakaya Kikwete of Tanzania launched a series of country briefs, co-authored by E2Pi, ALMA, and CHAI, that focuses on the benefits of sustaining malaria control programs in Ethiopia, Rwanda, Senegal, Mainland Tanzania, and Zanzibar. The launch received press coverage in the BMJ and the Lancet.

Maintaining the Gains in Malaria Control: The Health and Economic Benefits of Sustaining Control Measures
On October 17, 2011, at the second Bill & Melinda Gates Foundation Malaria Forum, E2Pi, ALMA, and CHAI launched a new report that:

  • Synthesizes evidence on the public health risks of ceasing malaria control activities in countries that still have transmission potential
  • Models the health and economic benefits of sustained malaria control in such countries
  • Lays out long-term financial sustainability plans for malaria programs

Additional E2Pi Publications on Malaria